{"id":799,"date":"2026-02-25T09:20:22","date_gmt":"2026-02-25T08:20:22","guid":{"rendered":"https:\/\/web.umons.ac.be\/biosciences\/?p=799"},"modified":"2026-02-25T09:20:22","modified_gmt":"2026-02-25T08:20:22","slug":"dun-labo-de-lumons-a-boston-le-pari-audacieux-disalyne-drewek","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/biosciences\/fr\/dun-labo-de-lumons-a-boston-le-pari-audacieux-disalyne-drewek\/","title":{"rendered":"D\u2019un labo de l\u2019UMONS \u00e0 Boston : le pari audacieux d\u2019Isalyne Drewek"},"content":{"rendered":"
\n

Depuis ses ann\u00e9es de master en chimie \u00e0 la Facult\u00e9 des Sciences de l\u2019UMONS, Isalyne Drewek suit un fil rouge : comprendre comment de simples mol\u00e9cules peuvent interagir avec le vivant. En fin de cursus, elle choisit l\u2019option chimie bio-inspir\u00e9e, attir\u00e9e par cette zone de rencontre entre chimie et biologie.<\/p>\n

Sa th\u00e8se, r\u00e9alis\u00e9e dans le laboratoire de Sophie Laurent (Service de Chimie g\u00e9n\u00e9rale, organique et biom\u00e9dicale), sous la tutelle de Dimitri Stanicki et en co-promotion Ruddy Wattiez, gr\u00e2ce \u00e0 une bourse FRIA du FNRS, marque un v\u00e9ritable tournant. Son projet portait sur un ph\u00e9nom\u00e8ne de floculation bact\u00e9rienne induite par de petites mol\u00e9cules d\u00e9riv\u00e9es du benzimidazole. Concr\u00e8tement, la floculation bact\u00e9rienne correspond \u00e0 l\u2019agr\u00e9gation de bact\u00e9ries en amas visibles, un peu comme si des cellules microscopiques se regroupaient en \u00ab flocons \u00bb. Ce processus peut modifier profond\u00e9ment leur comportement et leurs interactions.<\/span><\/p>\n

\u00ab <\/span>Le tournant d\u00e9cisif de mon parcours s\u2019est produit durant ma th\u00e8se, de mani\u00e8re assez inattendue<\/i> \u00bb, explique-t-elle. Ses travaux ont permis de mettre en \u00e9vidence un m\u00e9canisme original : l\u2019auto-assemblage de ces mol\u00e9cules en fibres supramol\u00e9culaires nanom\u00e9triques, directement responsables de cette agr\u00e9gation bact\u00e9rienne.<\/span><\/p>\n

\u00ab <\/span>Cette d\u00e9couverte m\u2019a amen\u00e9e \u00e0 m\u2019int\u00e9resser plus largement \u00e0 la chimie supramol\u00e9culaire et aux nanotechnologies, ainsi qu\u2019\u00e0 leur potentiel dans divers domaines, notamment dans le secteur de la sant\u00e9 \u00bb.<\/i><\/p><\/blockquote>\n

Au fil de ses recherches, elle d\u00e9veloppe un profil r\u00e9solument multidisciplinaire, combinant chimie organique, microbiologie, physico-chimie et, plus r\u00e9cemment, prot\u00e9omique.<\/span><\/p>\n

Cap sur Boston : cibler le cancer avec des nanostructures intelligentes<\/b><\/h5>\n

Ce cheminement la conduira dans les prochains mois \u00e0 Brandeis University, au sein du laboratoire du Professeur Bing Xu, une opportunit\u00e9 rendue possible par l\u2019obtention de la bourse de la <\/span>Belgian American Educational Foundation <\/i>(BAEF). Pionnier de la technologie <\/span>enzyme-instructed self-assembly<\/i> (EISA), Bing Xu a d\u00e9velopp\u00e9 une approche o\u00f9 de petites mol\u00e9cules s\u2019assemblent en nanostructures uniquement dans l\u2019environnement tumoral, sous l\u2019action d\u2019enzymes sp\u00e9cifiques.<\/span><\/p>\n

\u00ab J\u2019ai \u00e9t\u00e9 imm\u00e9diatement fascin\u00e9e par cette approche<\/i> \u00bb, confie Isalyne Drewek, qu\u2019elle a d\u00e9couverte lors d\u2019une conf\u00e9rence en Guadeloupe. Son projet \u00e0 Boston visera \u00e0 d\u00e9velopper des syst\u00e8mes peptidiques capables de s\u2019auto-assembler s\u00e9lectivement dans l\u2019environnement tumoral afin d\u2019induire la mort des cellules canc\u00e9reuses.<\/span><\/p>\n

L\u2019objectif est ambitieux : concevoir un agent \u201cdual-targeting\u201d ciblant \u00e0 la fois le cancer de la prostate et les m\u00e9tastases osseuses, particuli\u00e8rement fr\u00e9quentes et associ\u00e9es \u00e0 une morbidit\u00e9 \u00e9lev\u00e9e.<\/span><\/p>\n

\u00ab <\/span>\u00c0 long terme, j\u2019esp\u00e8re que mes recherches contribueront au d\u00e9veloppement de nouvelles strat\u00e9gies th\u00e9rapeutiques plus efficaces et mieux cibl\u00e9es, permettant de traiter certains cancers et leurs m\u00e9tastases tout en r\u00e9duisant les effets secondaires<\/i> \u00bb, souligne-t-elle.<\/span><\/p><\/blockquote>\n

Plus qu\u2019un d\u00e9part \u00e0 l\u2019\u00e9tranger, cette \u00e9tape \u00e0 Boston s\u2019inscrit dans une trajectoire scientifique patiemment construite, guid\u00e9e par la curiosit\u00e9 et la rigueur. \u00ab <\/span>Il est important de rester curieux et de ne pas avoir peur d\u2019explorer de nouveaux domaines<\/i> \u00bb, confie-t-elle. <\/span>Une conviction forg\u00e9e \u00e0 l\u2019UMONS et qu\u2019elle emportera avec elle aux \u00c9tats-Unis, avec l\u2019ambition de faire dialoguer durablement recherche fondamentale et applications en sant\u00e9.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Chercheuse au sein du service de Prot\u00e9omie et Microbiologie de l\u2019UMONS, dirig\u00e9 par le Professeur Ruddy Wattiez, Isalyne Drewek vient d\u2019obtenir une prestigieuse bourse de la Belgian American Educational Foundation (BAEF). Une reconnaissance internationale qui la m\u00e8nera \u00e0 Boston, \u00e0 Brandeis University. Au-del\u00e0 de la distinction, c\u2019est le parcours coh\u00e9rent et passionn\u00e9 d\u2019une jeune scientifique, form\u00e9e \u00e0 l\u2019interface de la chimie et de la biologie, qui se dessine.<\/p>\n","protected":false},"author":209,"featured_media":802,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[65,57,67,55],"tags":[],"class_list":["post-799","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-institution","category-international","category-prix-bourses-et-distinctions","category-recherche"],"yoast_head":"\nD\u2019un labo de l\u2019UMONS \u00e0 Boston : le pari audacieux d\u2019Isalyne Drewek - Institut \/ Biosciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/biosciences\/fr\/dun-labo-de-lumons-a-boston-le-pari-audacieux-disalyne-drewek\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u2019un labo de l\u2019UMONS \u00e0 Boston : le pari audacieux d\u2019Isalyne Drewek - Institut \/ Biosciences\" \/>\n<meta property=\"og:description\" content=\"Chercheuse au sein du service de Prot\u00e9omie et Microbiologie de l\u2019UMONS, dirig\u00e9 par le Professeur Ruddy Wattiez, Isalyne Drewek vient d\u2019obtenir une prestigieuse bourse de la Belgian American Educational Foundation (BAEF). 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