{"id":17,"date":"2021-11-04T13:55:39","date_gmt":"2021-11-04T12:55:39","guid":{"rendered":"https:\/\/web.umons.ac.be\/cell\/research-activities\/"},"modified":"2023-03-10T10:26:22","modified_gmt":"2023-03-10T09:26:22","slug":"research-activities","status":"publish","type":"page","link":"https:\/\/web.umons.ac.be\/cell\/en\/research-activities\/","title":{"rendered":"Research activities"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Two main research axes<\/strong> are developed within the Cell Biology laboratory.<\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #004c93;\"><strong>1. \u00a0Functional viral Interactomics<\/strong> (Prof. Tafforeau)<\/span><\/p>\n<p>This first research axe consists to study how a virus, when it is infecting a cell, hijacks cellular functions to its own profit. More particularly, we are interesting to the interactions between the flu virus (Infleunza A virus) proteins and few cellular pathways. We are identifying the interactions between viral and cellular proteins, and we are characterizing their functional implications in the viral infection cycle.<\/p>\n<p style=\"text-align: justify;\">Two research projects are currently underway :<\/p>\n<ul>\n<li style=\"text-align: justify;\">The functional characterization of the interplay between the viral proteins NS1 and PA-X and the cellular translation machinery. Indeed, these viral proteins particularly interact with several proteins involved in translation, i.e. protein synthesis through ribosomes.<\/li>\n<li style=\"text-align: justify;\">The identification of interactions between NS1 and the ubiquitin-proteasome system, and the functional deciphering of specific interactions, as for example the cell cycle regulation.<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\"><strong><span style=\"color: #004c93;\">2. \u00a0Molecular mechanisms of the human fertility<\/span><\/strong><span style=\"color: #004c93;\">\u00a0(Dr. Hennebert)<\/span><\/p>\n<p>The second research axe aims to identify and determine the functional role of proteins involved in human male fertility.<\/p>\n<p>Three projects are currently underway :<\/p>\n<ul>\n<li>The study of the HSP70 protein in order to understand its involvement in sperm\u00a0 mobility.<\/li>\n<li>The characterization of CRISP2, a sperm cell protein involved in the fusion with the oocyte, and the identification of its oocyte interactor.<\/li>\n<li>The highlighting of synthesized proteins in sperm cell following various treatments.<\/li>\n<\/ul>\n<hr \/>\n<p>Our unit is also associated with the following UMONS research institutes :<\/p>\n<start-cask-shortcode-wrapper>\t\t<div class=\"associated-institutes content-block scheme-fs\">\n\t\t\t<ul class=\"institutes-list\">\n\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t<a href=\"https:\/\/web.umons.ac.be\/biosciences\" title=\"Acc\u00e9der au site web de : Institut \/ Biosciences\" class=\"associated-institute\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/30\/2017\/11\/biosciences_logo_fr.svg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" \/>\t\t\t\t\t\t\t<\/a>\t\t\t\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t<a href=\"https:\/\/web.umons.ac.be\/sante\" title=\"Acc\u00e9der au site web de : Institut \/ Sant\u00e9\" class=\"associated-institute\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/35\/2021\/03\/sante_logo_fr.svg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" \/>\t\t\t\t\t\t\t<\/a>\t\t\t\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n <end-cask-shortcode-wrapper>\n","protected":false},"excerpt":{"rendered":"<p>Two main research axes are developed within the Cell Biology laboratory. 1. \u00a0Functional viral Interactomics (Prof. Tafforeau) This first research axe consists to study how a virus, when it is infecting a cell, hijacks cellular functions to its own profit. More particularly, we are interesting to the interactions between the flu virus (Infleunza A virus) [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research activities - Service \/ FS - Biologie Cellulaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/cell\/en\/research-activities\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research activities - Service \/ FS - Biologie Cellulaire\" \/>\n<meta property=\"og:description\" content=\"Two main research axes are developed within the Cell Biology laboratory. 1. \u00a0Functional viral Interactomics (Prof. Tafforeau) This first research axe consists to study how a virus, when it is infecting a cell, hijacks cellular functions to its own profit. 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