{"id":15,"date":"2021-11-19T11:34:27","date_gmt":"2021-11-19T10:34:27","guid":{"rendered":"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/"},"modified":"2021-11-19T11:50:50","modified_gmt":"2021-11-19T10:50:50","slug":"activites-de-recherche","status":"publish","type":"page","link":"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/","title":{"rendered":"Activit\u00e9s de recherche"},"content":{"rendered":"<p>Les projets de recherche d\u00e9velopp\u00e9s au sein du PhRR concernent l\u2019adaptation de l\u2019organisme \u00e0 diff\u00e9rentes conditions physiologiques et pathologiques, avec un int\u00e9r\u00eat particulier pour le tissu musculaire et ses relations avec l\u2019oxyg\u00e8ne.<\/p>\n<p>Dans ce contexte, le PhRR a d\u00e9velopp\u00e9 3 axes de recherches :<\/p>\n<ul>\n<li>les pathologies respiratoires (BPCO : BronchoPneumopathie Chronique Obstructive, SAOS : Syndrome d\u2019Apn\u00e9e Obstructive du Sommeil),<\/li>\n<li>l\u2019exercice physique,<\/li>\n<li>les myopathies h\u00e9r\u00e9ditaires et acquises (DMA : Atrophie musculaire d\u2019inemploi, FSHD : Dystrophie Facio-Scapulo-Hum\u00e9rale).<\/li>\n<\/ul>\n<p>L\u2019approche de recherche se veut translationnelle et int\u00e8gre :<\/p>\n<ul>\n<li>des \u00e9tudes cliniques,<\/li>\n<li>de l\u2019exp\u00e9rimentation in vivo (reconditionnement\/d\u00e9conditionnement musculaire, hypoxie continue et intermittente, \u00e9lectroporation de transg\u00e8nes, \u2026),<\/li>\n<li>des \u00e9tudes m\u00e9canistiques en culture cellulaire in vitro (macrophages, myoblastes, myotubes, fibres musculaires isol\u00e9es et cellules satellites \u2026)<\/li>\n<\/ul>\n<h3>Projets de recherche clefs<\/h3>\n<ul>\n<li>Etude de la communication entre le muscle et le cerveau dans un contexte d\u2019ob\u00e9sit\u00e9 : quel impact de l\u2019exercice physique ?<\/li>\n<li>Effets de l\u2019hypoxie intermittente sur les muscles respiratoires et locomoteurs dans le contexte du syndrome d\u2019apn\u00e9es obstructives du sommeil (SAOS)<\/li>\n<li>Etude de l\u2019effet de l\u2019hypox\u00e9mie sur les adipo\/myokines dans le contexte de la BPCO<\/li>\n<li>Etude du Crosstalk entre DUX4 et le facteur induit par l\u2019hypoxie (HIF1) dans le contexte de la FSHD<\/li>\n<li>La voie de l\u2019adiponectine: cible th\u00e9rapeutique pour contrer le d\u00e9conditionnement musculaire ?<\/li>\n<li>Ciblage au muscle d\u2019agents antisens \u00e0 vis\u00e9e th\u00e9rapeutique pour les myopathies.<\/li>\n<li>Etude translationnelle de la relation entre la fonction musculaire et respiratoire chez les patients FSHD: d\u00e9veloppement de crit\u00e8res d\u2019\u00e9valuation cliniques et mol\u00e9culaires.<\/li>\n<\/ul>\n<h3>Projets collaboratifs et consortium<\/h3>\n<ul>\n<li>Consortium ORGANCROSSTALK \u2013 Institut Sant\u00e9.<\/li>\n<li>Lab. Neurosciences : \u00ab R\u00f4le du stress oxydatif et de la neuroinflammation dans les troubles cognitifs associ\u00e9s \u00e0 l\u2019hypox\u00e9mie \u00e9pisodique : approche multidimensionnelle dans un mod\u00e8le murin \u00bb.<\/li>\n<li>Lab. Biochimie M\u00e9tabolique et Mol\u00e9culaire : \u00ab M\u00e9canismes Physiopathologiques et Mol\u00e9culaires associ\u00e9s \u00e0 l\u2019accumulation intramusculaire de tissus adipeux \u00bb.<\/li>\n<li>Lab. Biochimie M\u00e9tabolique et Mol\u00e9culaire : \u00ab Activation de l\u2019AMPK : une strat\u00e9gie th\u00e9rapeutique contre les alt\u00e9rations m\u00e9taboliques dans la FSHD ? \u00bb.<\/li>\n<li>Lab. cardiologie et Lab. Chimie G\u00e9n\u00e9rale, organique et Biom\u00e9dicale : \u00ab D\u00e9pistage de l\u00e9sions ath\u00e9romateuses dans un mod\u00e8le murin transg\u00e9nique expos\u00e9 \u00e0 l\u2019hypoxie intermittente par nanoplateformes ciblant VCAM d\u00e9tectables en RMN et imagerie optique \u00bb.<\/li>\n<\/ul>\n<h3>Publications<\/h3>\n<p>https:\/\/staff.umons.ac.be\/alexandre.legrand\/pubsFr.html<\/p>\n<p>https:\/\/staff.umons.ac.be\/Alexandra.Tassin\/pubsfr.html<\/p>\n<h3>Collaborations<\/h3>\n<ul>\n<li>Institut Sant\u00e9 : Lab. Biochimie M\u00e9tabolique et Mol\u00e9culaire (Prof. AE Decl\u00e8ves, Dr. F. Copp\u00e9e), Lab. Neurosciences (Prof. L. Ris, Dr. A. Villers), Lab. Biologie humaine et toxicologie (Prof. JM Collet, Dr. V. Tagliatti), Lab. Histologie (Prof. D. Nonclercq), Lab. Cardiologie (Prof. S. Carlier), Lab. Chimie g\u00e9n\u00e9rale, organique et biom\u00e9dicale (Prof. S. Laurent, Dr. C. Burtea), CMMI : Centre de Microscopie et d\u2019Imagerie Mol\u00e9culaire (Prof. S. Laurent, Dr. S. Boutry), Lab. S\u00e9miologie (Prof. D. Vanpee).<\/li>\n<li>Institut Biosciences : M\u00e9canobiologie &amp; Soft Matter Group (Prof. S. Gabriel).<\/li>\n<li>Laboratory of Polymeric and Composite Materials (LPMC) \u2013 Materia Nova : Prof. JM. Raquez &amp; Dr. R. Micheva<\/li>\n<li>ULB \u2013 Lab. M\u00e9decine Exp\u00e9rimentale : Prof. K. Zouaoui Boudjeltia<\/li>\n<li>UCLouvain : Prof. P. Sonveaux<\/li>\n<li>Universit\u00e9 de Montpellier : Prof. D. Laoudj-Chenivesse<\/li>\n<li>King\u2019s College of London : Prof. P. Zammit<\/li>\n<li>CHU Li\u00e8ge : Prof. J. Pincemail<\/li>\n<li>CHR Citadelle : Prof. L. Servaix<\/li>\n<\/ul>\n<hr \/>\n<p>Notre service est, par ailleurs rattach\u00e9 \u00e0 un institut de recherche de l\u2019UMONS :<\/p>\n<start-cask-shortcode-wrapper>\t\t<div class=\"associated-institutes content-block scheme-fmp\">\n\t\t\t<ul class=\"institutes-list\">\n\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t<a href=\"https:\/\/web.umons.ac.be\/sante\" title=\"Acc\u00e9der au site web de : Institut \/ Sant\u00e9\" class=\"associated-institute\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/35\/2021\/03\/sante_logo_fr.svg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" \/>\t\t\t\t\t\t\t<\/a>\t\t\t\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n <end-cask-shortcode-wrapper>\n","protected":false},"excerpt":{"rendered":"<p>Les projets de recherche d\u00e9velopp\u00e9s au sein du PhRR concernent l\u2019adaptation de l\u2019organisme \u00e0 diff\u00e9rentes conditions physiologiques et pathologiques, avec un int\u00e9r\u00eat particulier pour le tissu musculaire et ses relations avec l\u2019oxyg\u00e8ne. Dans ce contexte, le PhRR a d\u00e9velopp\u00e9 3 axes de recherches : les pathologies respiratoires (BPCO : BronchoPneumopathie Chronique Obstructive, SAOS : Syndrome [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-15","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Activit\u00e9s de recherche - Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Activit\u00e9s de recherche - Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire\" \/>\n<meta property=\"og:description\" content=\"Les projets de recherche d\u00e9velopp\u00e9s au sein du PhRR concernent l\u2019adaptation de l\u2019organisme \u00e0 diff\u00e9rentes conditions physiologiques et pathologiques, avec un int\u00e9r\u00eat particulier pour le tissu musculaire et ses relations avec l\u2019oxyg\u00e8ne. Dans ce contexte, le PhRR a d\u00e9velopp\u00e9 3 axes de recherches : les pathologies respiratoires (BPCO : BronchoPneumopathie Chronique Obstructive, SAOS : Syndrome [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire\" \/>\n<meta property=\"article:modified_time\" content=\"2021-11-19T10:50:50+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/\",\"url\":\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/\",\"name\":\"Activit\u00e9s de recherche - Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire\",\"isPartOf\":{\"@id\":\"https:\/\/web.umons.ac.be\/phrr\/#website\"},\"datePublished\":\"2021-11-19T10:34:27+00:00\",\"dateModified\":\"2021-11-19T10:50:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/web.umons.ac.be\/phrr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Activit\u00e9s de recherche\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/web.umons.ac.be\/phrr\/#website\",\"url\":\"https:\/\/web.umons.ac.be\/phrr\/\",\"name\":\"Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/web.umons.ac.be\/phrr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Activit\u00e9s de recherche - Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/web.umons.ac.be\/phrr\/activites-de-recherche\/","og_locale":"fr_FR","og_type":"article","og_title":"Activit\u00e9s de recherche - Service \/ FMPB - Physiologie et r\u00e9adaptation respiratoire","og_description":"Les projets de recherche d\u00e9velopp\u00e9s au sein du PhRR concernent l\u2019adaptation de l\u2019organisme \u00e0 diff\u00e9rentes conditions physiologiques et pathologiques, avec un int\u00e9r\u00eat particulier pour le tissu musculaire et ses relations avec l\u2019oxyg\u00e8ne. 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