{"id":202,"date":"2022-05-20T11:16:07","date_gmt":"2022-05-20T09:16:07","guid":{"rendered":"https:\/\/web.umons.ac.be\/seco\/?page_id=202"},"modified":"2022-05-20T11:16:07","modified_gmt":"2022-05-20T09:16:07","slug":"metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses","status":"publish","type":"page","link":"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/","title":{"rendered":"Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-83\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--300x287.png\" alt=\"\" width=\"300\" height=\"287\" srcset=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--300x287.png 300w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--30x29.png 30w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--60x57.png 60w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--360x344.png 360w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic-.png 516w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Dynamic metabolic flux analysis is of paramount importance to understand the response of cells or micro-organisms to their time-varying culture environment.<\/p>\n<p>It is also conceptually and practically important to understand the link between detailed metabolic representations and macroscopic models describing the cell as a black-box processing extracellular substrates to extracellular products.<\/p>\n<p>In this fascinating field of investigation, some of our recent research focused on:<\/p>\n<ul>\n<li>the development of Flux Variability Analysis (FVA) tools with minimum relaxation of the constraints<\/li>\n<li>the development of dynamic models of the virus amplification in Vero cell cultures for the production of vaccines<\/li>\n<li>the inference of minimal, suboptimal, sets of elementary flux modes for dynamic metabolic modeling<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Dynamic metabolic flux analysis is of paramount importance to understand the response of cells or micro-organisms to their time-varying culture environment. It is also conceptually and practically important to understand the link between detailed metabolic representations and macroscopic models describing the cell as a black-box processing extracellular substrates to extracellular products. In this fascinating field [&hellip;]<\/p>\n","protected":false},"author":95,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-202","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses - Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses - Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation\" \/>\n<meta property=\"og:description\" content=\"Dynamic metabolic flux analysis is of paramount importance to understand the response of cells or micro-organisms to their time-varying culture environment. It is also conceptually and practically important to understand the link between detailed metabolic representations and macroscopic models describing the cell as a black-box processing extracellular substrates to extracellular products. In this fascinating field [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--300x287.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/\",\"url\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/\",\"name\":\"Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses - Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation\",\"isPartOf\":{\"@id\":\"https:\/\/web.umons.ac.be\/seco\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--300x287.png\",\"datePublished\":\"2022-05-20T09:16:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/#primaryimage\",\"url\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--300x287.png\",\"contentUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/76\/2022\/05\/Metabolic--300x287.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/web.umons.ac.be\/seco\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/web.umons.ac.be\/seco\/#website\",\"url\":\"https:\/\/web.umons.ac.be\/seco\/\",\"name\":\"Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/web.umons.ac.be\/seco\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses - Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/web.umons.ac.be\/seco\/metabolic-flux-analysis-micro-and-macroscopic-modeling-of-bioprocesses\/","og_locale":"fr_FR","og_type":"article","og_title":"Metabolic flux analysis \u2013 micro- and macroscopic modeling of bioprocesses - Service \/ FPMS - Syst\u00e8mes, Estimation, Commande et Optimisation","og_description":"Dynamic metabolic flux analysis is of paramount importance to understand the response of cells or micro-organisms to their time-varying culture environment. 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