{"id":206,"date":"2019-09-11T10:04:54","date_gmt":"2019-09-11T08:04:54","guid":{"rendered":"https:\/\/web.umons.ac.be\/smos\/?p=206"},"modified":"2022-05-24T10:11:53","modified_gmt":"2022-05-24T08:11:53","slug":"new-paper-on-ion-mobility-for-natural-product-analysis-in-collaboration-with-waters-uk","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/smos\/2019\/09\/11\/new-paper-on-ion-mobility-for-natural-product-analysis-in-collaboration-with-waters-uk\/","title":{"rendered":"New paper on Ion Mobility for Natural Product Analysis in collaboration with Waters UK"},"content":{"rendered":"<figure id=\"attachment_207\" aria-describedby=\"caption-attachment-207\" style=\"width: 883px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-207\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11.png\" alt=\"New paper on Ion Mobility for Natural Product Analysis in collaboration with Waters UK\" width=\"883\" height=\"691\" srcset=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11.png 883w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11-300x235.png 300w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11-768x601.png 768w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11-843x660.png 843w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11-30x23.png 30w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11-60x47.png 60w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11-360x282.png 360w\" sizes=\"auto, (max-width: 883px) 100vw, 883px\" \/><figcaption id=\"caption-attachment-207\" class=\"wp-caption-text\">New paper on Ion Mobility for Natural Product Analysis in collaboration with Waters UK<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>In collaboration with scientists @ Waters UK, we demonstrated that regioisomeric and stereoisomeric saponins may be distinguished using cyclic ion mobility experiments.<\/p>\n<p>The full paper will be published in the <strong>Journal of The American Society for Mass Spectrometry<\/strong>.<u><\/u><\/p>\n<p><em>Aesculus hippocastanum,<\/em> commonly known as the horse chestnut tree or conker tree, is a well-known large tree, abundantly cultivated in streets and parks in temperate countries, especially in western Europe. Its seeds are well-known to contain saponin congeners presenting different compositions and different structures. The HC saponin extract is particularly challenging from an analytical point of view since regioisomeric and stereoisomeric saponins are present. In the present paper, it has been shown that ion mobility experiments together with liquid chromatography separation can be utilized for the structural characterization of stereoisomeric and regioisomeric saponins. Saponins presenting isomeric side chains, such as tiglic and angelic acid residues, can be distinguished by recording the Arrival Time Distributions (ATD), provided that high resolution ion mobility separation is used. This was demonstrated by comparing the capabilities of the Waters SYNAPT G2-S<em>i<\/em> mass spectrometer equipped with a conventional TWIMS device to an experimental cyclic ion mobility system (cIM) setup. Based on higher ion mobility resolution due to the multi-pass IMS<sup>n<\/sup> experiments and versatile fragmentation\/spectrum clean-up\/ion manipulation capabilities, we succeeded in discriminating stereoisomeric and regioisomeric natural molecules. The present work suggests that natural product analysis will benefit enormously from improvements in ion mobility techniques, in particular increased resolution.<\/p>\n<p><em><u>Colson, E., Decroo, C., Cooper-Shepherd, D. et al. J. Am. Soc. Mass Spectrom. <\/u><\/em><em><u>(2019). <\/u><\/em><\/p>\n<p>&nbsp;<\/p>\n<p><em><u><a href=\"https:\/\/doi.org\/10.1007\/s13361-019-02310-7\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1007\/s13361-019-02310-7<\/a><\/u><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the present paper, it has been shown that ion mobility experiments together with liquid chromatography separation can be utilized for the structural characterization of stereoisomeric and regioisomeric saponins. Saponins presenting isomeric side chains, such as tiglic and angelic acid residues, can be distinguished by recording the Arrival Time Distributions (ATD), provided that high resolution ion mobility separation is used. &#8230;<\/p>\n","protected":false},"author":157,"featured_media":207,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-206","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New paper on Ion Mobility for Natural Product Analysis in collaboration with Waters UK - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques<\/title>\n<meta name=\"robots\" content=\"index,follow\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/smos\/2019\/09\/11\/new-paper-on-ion-mobility-for-natural-product-analysis-in-collaboration-with-waters-uk\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper on Ion Mobility for Natural Product Analysis in collaboration with Waters UK - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"og:description\" content=\"In the present paper, it has been shown that ion mobility experiments together with liquid chromatography separation can be utilized for the structural characterization of stereoisomeric and regioisomeric saponins. Saponins presenting isomeric side chains, such as tiglic and angelic acid residues, can be distinguished by recording the Arrival Time Distributions (ATD), provided that high resolution ion mobility separation is used. ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/smos\/2019\/09\/11\/new-paper-on-ion-mobility-for-natural-product-analysis-in-collaboration-with-waters-uk\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-11T08:04:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-24T08:11:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/20219-09-11.png\" \/>\n\t<meta property=\"og:image:width\" content=\"883\" \/>\n\t<meta property=\"og:image:height\" content=\"691\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Eric Weverbergh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eric Weverbergh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/09\/11\/new-paper-on-ion-mobility-for-natural-product-analysis-in-collaboration-with-waters-uk\/\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/2019\/09\/11\/new-paper-on-ion-mobility-for-natural-product-analysis-in-collaboration-with-waters-uk\/\",\"name\":\"New paper on Ion Mobility for Natural Product Analysis in collaboration with Waters UK - 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