{"id":233,"date":"2019-04-05T11:02:12","date_gmt":"2019-04-05T09:02:12","guid":{"rendered":"https:\/\/web.umons.ac.be\/smos\/?p=233"},"modified":"2022-05-24T11:04:30","modified_gmt":"2022-05-24T09:04:30","slug":"new-paper-in-the-collaboration-with-the-erasmus-university-medical-center","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/","title":{"rendered":"New paper in the collaboration with the Erasmus University Medical Center"},"content":{"rendered":"<figure id=\"attachment_234\" aria-describedby=\"caption-attachment-234\" style=\"width: 571px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-234 size-full\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png\" alt=\"New paper in the collaboration with the Erasmus University Medical Center\" width=\"571\" height=\"418\" srcset=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png 571w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05-300x220.png 300w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05-30x22.png 30w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05-60x44.png 60w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05-360x264.png 360w\" sizes=\"auto, (max-width: 571px) 100vw, 571px\" \/><figcaption id=\"caption-attachment-234\" class=\"wp-caption-text\">Figure : Ratio between the modified and unmodified peptides (GLHGEFGLP(4Hyp)GP(Pro)AGPR and GLHGEFGLP(4Hyp)GP(?xHyp)AGPR, respectively)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>A paper entitled \u201cIdentification of 4-Hydroxyproline at the Xaa Position in Collagen by Mass Spectrometry\u201d has just been accepted for publication in the Journal of Proteome Research, an ACS scientific journal.<\/p>\n<p>The paper concerns the identification of an enzymatic structural modification of the proline residues of collagen by mass spectrometry.<\/p>\n<p>Collagen has a triple helix form, structured by a [-Gly-Xaa-Yaa-] repetition, where Xaa and Yaa are amino acids. This repeating unit can be post-translationally modified by enzymes, where proline is often hydroxylated into hydroxyproline (Hyp). Two Hyp isomers occur in collagen: 4-hydroxyproline (4Hyp) and 3-hydroxyproline (3Hyp).<\/p>\n<p>We showed that proline, at position 584 in COL1A2, has a lower rate of modification in colorectal liver metastasis tissue than in healthy liver, but the isomeric identity of ?xHyp, i.e. 3- and\/or 4Hyp, remained unknown.<\/p>\n<p>We here present a proof of principle identification of ?xHyp. This identification is based on liquid chromatography retention time differences and mass spectrometry using ETD-HCD fragmentation, complemented by ab initio calculations.<\/p>\n<p>Both techniques identify ?xHyp at position 584 in COL1A2 as 4-hydroxyproline (4xHyp).<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A paper entitled \u201cIdentification of 4-Hydroxyproline at the Xaa Position in Collagen by Mass Spectrometry\u201d has just been accepted for publication in the Journal of Proteome Research, an ACS scientific journal.<\/p>\n","protected":false},"author":157,"featured_media":234,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-233","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New paper in the collaboration with the Erasmus University Medical Center - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper in the collaboration with the Erasmus University Medical Center - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"og:description\" content=\"A paper entitled \u201cIdentification of 4-Hydroxyproline at the Xaa Position in Collagen by Mass Spectrometry\u201d has just been accepted for publication in the Journal of Proteome Research, an ACS scientific journal.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"article:published_time\" content=\"2019-04-05T09:02:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-24T09:04:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png\" \/>\n\t<meta property=\"og:image:width\" content=\"571\" \/>\n\t<meta property=\"og:image:height\" content=\"418\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Eric Weverbergh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eric Weverbergh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\"},\"author\":{\"name\":\"Eric Weverbergh\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782\"},\"headline\":\"New paper in the collaboration with the Erasmus University Medical Center\",\"datePublished\":\"2019-04-05T09:02:12+00:00\",\"dateModified\":\"2022-05-24T09:04:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\"},\"wordCount\":218,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png\",\"articleSection\":[\"Recherche\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\",\"name\":\"New paper in the collaboration with the Erasmus University Medical Center - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\",\"isPartOf\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png\",\"datePublished\":\"2019-04-05T09:02:12+00:00\",\"dateModified\":\"2022-05-24T09:04:30+00:00\",\"author\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782\"},\"breadcrumb\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage\",\"url\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png\",\"contentUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png\",\"width\":571,\"height\":418,\"caption\":\"New paper in the collaboration with the Erasmus University Medical Center\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/web.umons.ac.be\/smos\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New paper in the collaboration with the Erasmus University Medical Center\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#website\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/\",\"name\":\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/web.umons.ac.be\/smos\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782\",\"name\":\"Eric Weverbergh\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g\",\"caption\":\"Eric Weverbergh\"},\"url\":\"https:\/\/web.umons.ac.be\/smos\/author\/eweverbergh\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New paper in the collaboration with the Erasmus University Medical Center - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/","og_locale":"fr_FR","og_type":"article","og_title":"New paper in the collaboration with the Erasmus University Medical Center - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","og_description":"A paper entitled \u201cIdentification of 4-Hydroxyproline at the Xaa Position in Collagen by Mass Spectrometry\u201d has just been accepted for publication in the Journal of Proteome Research, an ACS scientific journal.","og_url":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/","og_site_name":"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","article_published_time":"2019-04-05T09:02:12+00:00","article_modified_time":"2022-05-24T09:04:30+00:00","og_image":[{"width":571,"height":418,"url":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png","type":"image\/png"}],"author":"Eric Weverbergh","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Eric Weverbergh","Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#article","isPartOf":{"@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/"},"author":{"name":"Eric Weverbergh","@id":"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782"},"headline":"New paper in the collaboration with the Erasmus University Medical Center","datePublished":"2019-04-05T09:02:12+00:00","dateModified":"2022-05-24T09:04:30+00:00","mainEntityOfPage":{"@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/"},"wordCount":218,"commentCount":0,"image":{"@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage"},"thumbnailUrl":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png","articleSection":["Recherche"],"inLanguage":"fr-FR","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/","url":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/","name":"New paper in the collaboration with the Erasmus University Medical Center - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","isPartOf":{"@id":"https:\/\/web.umons.ac.be\/smos\/#website"},"primaryImageOfPage":{"@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage"},"image":{"@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage"},"thumbnailUrl":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png","datePublished":"2019-04-05T09:02:12+00:00","dateModified":"2022-05-24T09:04:30+00:00","author":{"@id":"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782"},"breadcrumb":{"@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#primaryimage","url":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png","contentUrl":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/article-2019-04-05.png","width":571,"height":418,"caption":"New paper in the collaboration with the Erasmus University Medical Center"},{"@type":"BreadcrumbList","@id":"https:\/\/web.umons.ac.be\/smos\/2019\/04\/05\/new-paper-in-the-collaboration-with-the-erasmus-university-medical-center\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/web.umons.ac.be\/smos\/"},{"@type":"ListItem","position":2,"name":"New paper in the collaboration with the Erasmus University Medical Center"}]},{"@type":"WebSite","@id":"https:\/\/web.umons.ac.be\/smos\/#website","url":"https:\/\/web.umons.ac.be\/smos\/","name":"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/web.umons.ac.be\/smos\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782","name":"Eric Weverbergh","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g","caption":"Eric Weverbergh"},"url":"https:\/\/web.umons.ac.be\/smos\/author\/eweverbergh\/"}]}},"lang":"fr","translations":{"fr":233},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts\/233","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/users\/157"}],"replies":[{"embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/comments?post=233"}],"version-history":[{"count":1,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts\/233\/revisions"}],"predecessor-version":[{"id":235,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts\/233\/revisions\/235"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/media\/234"}],"wp:attachment":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/media?parent=233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/categories?post=233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/tags?post=233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}