{"id":281,"date":"2021-08-24T14:57:48","date_gmt":"2021-08-24T12:57:48","guid":{"rendered":"https:\/\/web.umons.ac.be\/smos\/?p=281"},"modified":"2023-02-10T14:15:14","modified_gmt":"2023-02-10T13:15:14","slug":"mass-spectrometry-analysis-of-saponins","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/smos\/2021\/08\/24\/mass-spectrometry-analysis-of-saponins\/","title":{"rendered":"Mass spectrometry analysis of saponins"},"content":{"rendered":"

\"\"<\/p>\n

Saponins are amphiphilic molecules of pharmaceutical interest and most of their biological activities (i.e., cytotoxic, hemolytic, fungicide, etc.) are associated to their membranolytic properties. These molecules are secondary metabolites present in numerous plants and in some marine animals, such as sea cucumbers and starfishes. Structurally, all saponins correspond to the combination of a hydrophilic glycan, consisting of sugar chain(s), linked to a hydrophobic triterpenoidic or steroidic aglycone, named the sapogenin. Saponins present a high structural diversity and their structural characterization remains extremely challenging. Ideally, saponin structures are best established using nuclear magnetic resonance experiments conducted on isolated molecules. However, the extreme structural diversity of saponins makes them ch<\/p>\n

allenging from a structural analysis point of view since, most of the time, saponin extracts consist in a huge number of congeners presenting only subtle structural differences. In the present review, we wish to offer an overview of the literature related to the development of mass spectrometry for the study of saponins. This review will demonstrate that most of the past and current mass spectrometry methods, including electron, electrospray and matrix-assisted laser desorption\/ionization ionizations, gas\/liquid chromatography coupled to (tandem) mass spectrometry, collision-induced dissociation including MS3<\/sup> experiments, multiple reaction monitoring based quantification, ion mobility experiments, and so forth, have been used for saponin investigations with great success on enriched extracts but also directly on tissues using imaging methods.<\/p>\n

doi:10.1002\/mas.21728\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Saponins are amphiphilic molecules of pharmaceutical interest and most of their biological activities (i.e., cytotoxic, hemolytic, fungicide, etc.) are associated to their membranolytic properties. These molecules are secondary metabolites present in numerous plants and in some marine animals…<\/p>\n","protected":false},"author":157,"featured_media":298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"yoast_head":"\nMass spectrometry analysis of saponins - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques<\/title>\n<meta name=\"robots\" content=\"index,follow\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/24\/mass-spectrometry-analysis-of-saponins\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mass spectrometry analysis of saponins - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"og:description\" content=\"Saponins are amphiphilic molecules of pharmaceutical interest and most of their biological activities (i.e., cytotoxic, hemolytic, fungicide, etc.) are associated to their membranolytic properties. These molecules are secondary metabolites present in numerous plants and in some marine animals...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/24\/mass-spectrometry-analysis-of-saponins\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-24T12:57:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-10T13:15:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2021\/08\/article_2021-08-30.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1247\" \/>\n\t<meta property=\"og:image:height\" content=\"933\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Eric Weverbergh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Philippe Savarino\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/24\/mass-spectrometry-analysis-of-saponins\/\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/24\/mass-spectrometry-analysis-of-saponins\/\",\"name\":\"Mass spectrometry analysis of saponins - 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