{"id":69,"date":"2021-08-30T14:50:34","date_gmt":"2021-08-30T12:50:34","guid":{"rendered":"https:\/\/web.umons.ac.be\/smos\/?p=69"},"modified":"2022-05-23T14:22:26","modified_gmt":"2022-05-23T12:22:26","slug":"new-paper-published-in-journal-of-medicinal-chemistry-in-collaboration-with-prof-stephane-vincent-from-unamur","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/smos\/2021\/08\/30\/new-paper-published-in-journal-of-medicinal-chemistry-in-collaboration-with-prof-stephane-vincent-from-unamur\/","title":{"rendered":"New paper published in Journal of Medicinal Chemistry in Collaboration with Prof Stephane Vincent from UNamur"},"content":{"rendered":"
\"Pillar[5]arene-Based
Pillar[5]arene-Based Polycationic Glyco[2]rotaxanes Designed as Pseudomonas aeruginosa Antibiofilm Agent<\/figcaption><\/figure>\n

Pseudomonas aeruginosa (P.A.) is a human pathogen belonging to the top priorities for the discovery of new therapeutic solutions. Its propensity to generate biofilms strongly complicates the treatments required to cure P.A. infections. Herein, we describe the synthesis of a series of novel rotaxanes composed of a central galactosylated pillar[5]arene, a tetrafucosylated dendron, and a tetraguanidinium subunit. Besides the high affinity of the final glycorotaxanes for the two P.A. lectins LecA and LecB, potent inhibition levels of biofilm growth were evidenced, showing that their three subunits work synergistically. An antibiofilm assay using a double \u0394lecA\u0394lecB mutant compared to the wild type demonstrated that the antibiofilm activity of the best glycorotaxane is lectin-mediated. Such antibiofilm potency had rarely been reached in the literature. Importantly, none of the final rotaxanes was bactericidal, showing that their antibiofilm activity does not depend on bacteria killing, which is a rare feature for antibiofilm agents. The contribution of our laboratory was the mass accuracy measurement of all the rotaxanes used in this study.<\/p>\n

https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.1c01241<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Pseudomonas aeruginosa (P.A.) is a human pathogen belonging to the top priorities for the discovery of new therapeutic solutions. Its propensity to generate biofilms strongly complicates the treatments required to cure P.A. infections. Herein, we describe the synthesis of a series of novel rotaxanes composed of a central galactosylated pillar[5]arene, a tetrafucosylated dendron, and a tetraguanidinium subunit. Besides the high affinity of the final glycorotaxanes for the two P.A. …<\/p>\n","protected":false},"author":157,"featured_media":70,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-69","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"yoast_head":"\nNew paper published in Journal of Medicinal Chemistry in Collaboration with Prof Stephane Vincent from UNamur - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques<\/title>\n<meta name=\"robots\" content=\"index,follow\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/30\/new-paper-published-in-journal-of-medicinal-chemistry-in-collaboration-with-prof-stephane-vincent-from-unamur\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper published in Journal of Medicinal Chemistry in Collaboration with Prof Stephane Vincent from UNamur - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"og:description\" content=\"Pseudomonas aeruginosa (P.A.) is a human pathogen belonging to the top priorities for the discovery of new therapeutic solutions. Its propensity to generate biofilms strongly complicates the treatments required to cure P.A. infections. Herein, we describe the synthesis of a series of novel rotaxanes composed of a central galactosylated pillar[5]arene, a tetrafucosylated dendron, and a tetraguanidinium subunit. Besides the high affinity of the final glycorotaxanes for the two P.A. ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/30\/new-paper-published-in-journal-of-medicinal-chemistry-in-collaboration-with-prof-stephane-vincent-from-unamur\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-30T12:50:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-23T12:22:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2021\/11\/2021-09-23_1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2096\" \/>\n\t<meta property=\"og:image:height\" content=\"903\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Eric Weverbergh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eric Weverbergh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/30\/new-paper-published-in-journal-of-medicinal-chemistry-in-collaboration-with-prof-stephane-vincent-from-unamur\/\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/2021\/08\/30\/new-paper-published-in-journal-of-medicinal-chemistry-in-collaboration-with-prof-stephane-vincent-from-unamur\/\",\"name\":\"New paper published in Journal of Medicinal Chemistry in Collaboration with Prof Stephane Vincent from UNamur - 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