{"id":76,"date":"2022-02-02T10:38:58","date_gmt":"2022-02-02T09:38:58","guid":{"rendered":"https:\/\/web.umons.ac.be\/smos\/?p=76"},"modified":"2022-05-23T14:17:27","modified_gmt":"2022-05-23T12:17:27","slug":"on-the-conformation-of-anionic-peptoids-in-the-gas-phase","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/","title":{"rendered":"On the Conformation of Anionic Peptoids in the Gas Phase"},"content":{"rendered":"<figure id=\"attachment_77\" aria-describedby=\"caption-attachment-77\" style=\"width: 1065px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-77\" src=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine.jpg\" alt=\"On the Conformation of Anionic Peptoids in the Gas Phase\" width=\"1065\" height=\"501\" srcset=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine.jpg 1065w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine-300x141.jpg 300w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine-1024x482.jpg 1024w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine-768x361.jpg 768w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine-30x14.jpg 30w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine-60x28.jpg 60w, https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine-360x169.jpg 360w\" sizes=\"auto, (max-width: 1065px) 100vw, 1065px\" \/><figcaption id=\"caption-attachment-77\" class=\"wp-caption-text\">On the Conformation of Anionic Peptoids in the Gas Phase<\/figcaption><\/figure>\n<p style=\"text-align: justify\">Although <em>N-(S)<\/em>-phenylethyl peptoids are known to adopt helical structures in solutions, the corresponding positively charged ions lose their helical structure during the transfer from the solution to the gas phase due to the so-called charge solvation effect. We, here, considered negatively charged peptoids to investigate by ion mobility spectrometry\u2212mass spectrometry whether the structural changes described in the positive ionization mode can be circumvented in the negative mode by a fine-tuning of the peptoid sequence, that is, by positioning the negative charge at the positive side of the helical peptoid macrodipole. <em>N-(S)<\/em>-(1- carboxy-2-phenylethyl) (<em>N<\/em>scp) and <em>N-(S)<\/em>-phenylethyl (<em>N<\/em>spe) were selected as the negative charge carrier and as the helix inductor, respectively. We, here, report the results of a joint theoretical and experimental study demonstrating that the structures adopted by the <em>N<\/em>spe<sub>n<\/sub><em>N<\/em>scp anions remain compactly folded in the gas phase for chains containing up to 10 residues, whereas no evidence of the presence of a helical structure was obtained, even if, for selected sequences and lengths, different gas phase conformations are detected.<\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.biomac.1c01442\" target=\"_blank\" rel=\"noopener\">10.1021\/acs.biomac.1c01442<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although N-(S)-phenylethyl peptoids are known to adopt helical structures in solutions, the corresponding positively charged ions lose their helical structure during the transfer from the solution to the gas phase due to the so-called charge solvation effect. We, here&#8230;<\/p>\n","protected":false},"author":157,"featured_media":77,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-76","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>On the Conformation of Anionic Peptoids in the Gas Phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"On the Conformation of Anionic Peptoids in the Gas Phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"og:description\" content=\"Although N-(S)-phenylethyl peptoids are known to adopt helical structures in solutions, the corresponding positively charged ions lose their helical structure during the transfer from the solution to the gas phase due to the so-called charge solvation effect. We, here...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-02T09:38:58+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-23T12:17:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1065\" \/>\n\t<meta property=\"og:image:height\" content=\"501\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Eric Weverbergh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eric Weverbergh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/\"},\"author\":{\"name\":\"Eric Weverbergh\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782\"},\"headline\":\"On the Conformation of Anionic Peptoids in the Gas Phase\",\"datePublished\":\"2022-02-02T09:38:58+00:00\",\"dateModified\":\"2022-05-23T12:17:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/\"},\"wordCount\":208,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/02\/2022-02-02_Perine.jpg\",\"articleSection\":[\"Recherche\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/2022\/02\/02\/on-the-conformation-of-anionic-peptoids-in-the-gas-phase\/\",\"name\":\"On the Conformation of Anionic Peptoids in the Gas Phase - 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