{"id":97,"date":"2021-07-09T10:45:21","date_gmt":"2021-07-09T08:45:21","guid":{"rendered":"https:\/\/web.umons.ac.be\/smos\/?p=97"},"modified":"2022-05-23T14:24:14","modified_gmt":"2022-05-23T12:24:14","slug":"just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase","status":"publish","type":"post","link":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/","title":{"rendered":"Just accepted paper: peptoids and hydrogen bonds in gas phase"},"content":{"rendered":"
\"peptoids
peptoids and hydrogen bonds in gas phase<\/figcaption><\/figure>\n

We recently reported a joint experimental and theoretical study of peptoid ions bearing (S)-N-1-phenylethyl side chains. In this study, we demonstrated that the gas phase conformation, probed by ion mobility mass spectrometry, was different from the solution phase conformation (loop vs. helix) because the charge, mandatory for mass spectrometry analysis, must be stabilized and causes the backbone to wrap around to maximize the ion-dipole interactions. In the present study, we introduce another side chain, (S)-N-(1-carboxy-2-phenylethyl), that can form hydrogen bonds. Molecular modeling and ion mobility mass spectrometry of these protonated peptoids strongly suggest that a helical conformation is obtained in gas phase, despite the need to stabilize the charge. This is due to the combination of a hydrogen bond network between the side chains and the backbone carbonyls, and the steric hindrance of the side chains.<\/p>\n","protected":false},"excerpt":{"rendered":"

We recently reported a joint experimental and theoretical study of peptoid ions bearing (S)-N-1-phenylethyl side chains. In this study, we demonstrated that the gas phase conformation, probed by ion mobility mass spectrometry, was different from the solution phase conformation (loop vs. helix) because the charge, mandatory for mass spectrometry analysis, must be stabilized and causes the backbone to wrap around to maximize the ion-dipole interactions.<\/p>\n","protected":false},"author":157,"featured_media":99,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-97","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"yoast_head":"\nJust accepted paper: peptoids and hydrogen bonds in gas phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques<\/title>\n<meta name=\"robots\" content=\"index,follow\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Just accepted paper: peptoids and hydrogen bonds in gas phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"og:description\" content=\"We recently reported a joint experimental and theoretical study of peptoid ions bearing (S)-N-1-phenylethyl side chains. In this study, we demonstrated that the gas phase conformation, probed by ion mobility mass spectrometry, was different from the solution phase conformation (loop vs. helix) because the charge, mandatory for mass spectrometry analysis, must be stabilized and causes the backbone to wrap around to maximize the ion-dipole interactions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/\" \/>\n<meta property=\"og:site_name\" content=\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-09T08:45:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-23T12:24:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2100\" \/>\n\t<meta property=\"og:image:height\" content=\"825\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Eric Weverbergh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eric Weverbergh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/\",\"name\":\"Just accepted paper: peptoids and hydrogen bonds in gas phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\",\"isPartOf\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg\",\"datePublished\":\"2021-07-09T08:45:21+00:00\",\"dateModified\":\"2022-05-23T12:24:14+00:00\",\"author\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782\"},\"breadcrumb\":{\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#primaryimage\",\"url\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg\",\"contentUrl\":\"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg\",\"width\":2100,\"height\":825,\"caption\":\"peptoids and hydrogen bonds in gas phase\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/web.umons.ac.be\/smos\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Just accepted paper: peptoids and hydrogen bonds in gas phase\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#website\",\"url\":\"https:\/\/web.umons.ac.be\/smos\/\",\"name\":\"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/web.umons.ac.be\/smos\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782\",\"name\":\"Eric Weverbergh\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g\",\"caption\":\"Eric Weverbergh\"},\"url\":\"https:\/\/web.umons.ac.be\/smos\/author\/eweverbergh\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Just accepted paper: peptoids and hydrogen bonds in gas phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","robots":{"index,follow":"index,follow"},"canonical":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/","og_locale":"fr_FR","og_type":"article","og_title":"Just accepted paper: peptoids and hydrogen bonds in gas phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","og_description":"We recently reported a joint experimental and theoretical study of peptoid ions bearing (S)-N-1-phenylethyl side chains. In this study, we demonstrated that the gas phase conformation, probed by ion mobility mass spectrometry, was different from the solution phase conformation (loop vs. helix) because the charge, mandatory for mass spectrometry analysis, must be stabilized and causes the backbone to wrap around to maximize the ion-dipole interactions.","og_url":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/","og_site_name":"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","article_published_time":"2021-07-09T08:45:21+00:00","article_modified_time":"2022-05-23T12:24:14+00:00","og_image":[{"width":2100,"height":825,"url":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg","type":"image\/jpeg"}],"author":"Eric Weverbergh","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Eric Weverbergh","Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/","url":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/","name":"Just accepted paper: peptoids and hydrogen bonds in gas phase - Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","isPartOf":{"@id":"https:\/\/web.umons.ac.be\/smos\/#website"},"primaryImageOfPage":{"@id":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#primaryimage"},"image":{"@id":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#primaryimage"},"thumbnailUrl":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg","datePublished":"2021-07-09T08:45:21+00:00","dateModified":"2022-05-23T12:24:14+00:00","author":{"@id":"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782"},"breadcrumb":{"@id":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#primaryimage","url":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg","contentUrl":"https:\/\/web.umons.ac.be\/app\/uploads\/sites\/80\/2022\/05\/2021-07-09_2.jpg","width":2100,"height":825,"caption":"peptoids and hydrogen bonds in gas phase"},{"@type":"BreadcrumbList","@id":"https:\/\/web.umons.ac.be\/smos\/2021\/07\/09\/just-accepted-paper-peptoids-and-hydrogen-bonds-in-gas-phase\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/web.umons.ac.be\/smos\/"},{"@type":"ListItem","position":2,"name":"Just accepted paper: peptoids and hydrogen bonds in gas phase"}]},{"@type":"WebSite","@id":"https:\/\/web.umons.ac.be\/smos\/#website","url":"https:\/\/web.umons.ac.be\/smos\/","name":"Service \/ FS - Synth\u00e8se et Spectrom\u00e9trie de Masse Organiques","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/web.umons.ac.be\/smos\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/799f9fff96a5393a6f974013d89f3782","name":"Eric Weverbergh","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/web.umons.ac.be\/smos\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/277eef236b3d46fa37342f3ff7201123ffcff78c8376e87dfb037d245a79e832?s=96&d=mm&r=g","caption":"Eric Weverbergh"},"url":"https:\/\/web.umons.ac.be\/smos\/author\/eweverbergh\/"}]}},"lang":"fr","translations":{"fr":97},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts\/97","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/users\/157"}],"replies":[{"embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/comments?post=97"}],"version-history":[{"count":2,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts\/97\/revisions"}],"predecessor-version":[{"id":127,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/posts\/97\/revisions\/127"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/media\/99"}],"wp:attachment":[{"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/media?parent=97"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/categories?post=97"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.umons.ac.be\/smos\/wp-json\/wp\/v2\/tags?post=97"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}