The researches of the laboratory focus on the cellular and molecular mechanisms of glutamatergic synaptic plasticity in the central nervous system in health and disease. Our approach consists of a combination of electrophysiological, molecular and cellular approaches. We develop and apply state-of-the-art electrophysiogical techniques. We combine this physiological read-out with behavioral measurements, immunohistochemistry and proteome analysis. We worked on normal mice and on animal models of disease, such as Alzheimer’s disease, auto-immune diseases or dopamine-related disorders.
Our laboratory is embedded in the UMONS Research Institutes for Health Science and Technologies and for Biosciences and is involved in national and international collaborations. Its research is supported by the Queen Elisabeth Found for Medical Research, the Charcot foundation, the Walloon region, F.R.S.-FNRS, FWO, ARES-CCD and the European Interreg Program.
Beside its activity in preclinical research, the laboratory also founded the Center for Interdisciplinary Research on Psychophysiology and Electrophysiology of Cognition (CiPSE) to approach complex cognitive processes from a broad perspective and the combination of multiple expertise such as Biology, Psychology, Medical sciences and engineering (Data Mining, AI) and developed a Master degree in biomedicine specialized in Neuroscience and covering three main areas: brain biology, computation and neural technology and clinical and cognitive neuroscience.