Multi-level blood flow simulation strategies accounting effects of red blood cells, White blood cells, clots and platelets and wall interactions.

Description

Due to the strong impact of blood flow behavior and pattern in the occurrence or the cure of cardiovascular diseases, the prediction of circulatory pathologies and the development of new drugs and treatments against these pathologies is requiring tools enabling to produce pulsatile flow conditions found in reality, ideally patient specific, to assess their effect. In order to avoid difficult in vivo investigations, virtual prototyping base on CFD models are tools more and more efficient and widely used. Due to the complexity of the flow behavior and interaction, at small scale of the blood formed element (red blood cells, with blood cells, platelets), the drugs or the treatments using devices such stent and filters, efficient simulation tools are required to capture the multiple scale of the physical phenomena in the flow. The PhD research aims at developing multiscale simulation methodologies to capture, efficiently a low CPU cost, both the large scale flow patterns driven by the non-Newtonian continuous fluid dynamics law (Navier-Stokes conservation equations) and the small scale motion of particles in the plasma using particles models (lattice Boltzmann, immersed boundary…).