Development of a molecule with several chemically equivalent F atoms, characterised by sufficiently short relaxation times to allow the recording of an MRI image under good conditions, as well as a biological vector capable of specific tissue targeting.

Description

Imaging techniques such as optical, photoacoustic and magnetic resonance are available at the Center for Microscopy and Molecular Imaging. There is a need for the development of methodologies allowing for optimization of protocols in mouse model studies. Animal models range from healthy animal to pathological (cancer, inflammation, atherosclerosis, neurodegenerative diseases) or therapeutic (anti-cancer, anti-angiogenic, apoptotic) situations. Imaging protocols often require contrast agent, tracer or substrate injection. Localization and/or distribution (in compartment, tissue, cells) of those compounds has to be optimally detected and followed up in time. Interpretation of signal modifications requires quantitative analysis of recorded images, potentially knowing how to use mathematical models (eg. kinetic modelling) that allow to obtain parameters reflecting the underlying physiopathology. Those small animal imaging techniques require Laboratory Animal Science certification for directing animal experiments. Development of an animal model in the context of a given study may be considered. In magnetic resonance, imaging sequences as well as spectroscopy sequences might have to be developed.