Binary and ternary separations in simulated moving bed processes

Simulated moving bed (SMB) chromatographic separation processes allows achieving delicate binary and ternary separations for various applications in the chemical, pharmaceutical and food sector.

This continuous process has number of decisive advantages such as lower solvent consumption, decreased energy consumption, more efficient use of  the stationary phase, continuous production of larger amount of purified material. However, the process operation has to be carefully optimized and monitored to avoid the detrimental effects of perturbations.

Over the years, we have been interested in various aspects of the process dynamic analysis, monitoring and control:

  • numerical simulation of the SMB operation
  • state estimation and adaptive control of SMB processes

Further reading

Efficient Simulation of Chromatographic Processes Using the Conservation Element/Solution Element Method by Valentin Plamenov Chernev, Alain Vande Wouwer and Achim Kienle Processes 2020, 8(10), 1316;